Abstract
Summary
Serotonin (5 -hydroxytrypta-mine) was found to produce a significant increase in radioiron incorporation in red cells of polycythemic mice. A linear dose-response relationship is reported. Anti-ESF produced a significant inhibition of the erythropoietic effects of 5-HT in polycythemic mice. However, residual erythropoietic activity was still seen even in the presence of antiserum to erythropoietin suggesting a secondary erythropoietic effect which is not erythropoietin dependent. Intrarenal infusions of 5-HT into dogs was found to produce a significant elevation in plasma erythropoietic activity.
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