The Variation of Glucose Metabolism in Human Erythrocytes in the Presence of L-Thyroxine 1

Abstract

Summary

Normal washed human erythrocytes, when incubated in a buffered saline solution (pH 7.5-7.6) with T₄ (3.75 X 10-8 M), demonstrated increased production of 2, 3-DPG and glucose consumption during the first 30 min of incubation. However, lactate production and ATP levels were decreased. The mechanism is probably related to a direct effect of T₄ on the diphosphoglycerate mutase.