Abstract
Summary
Germfree AKR mice were inoculated with cyclophosphamide at weekly intervals for long periods. Leukemia was prevented for 13 months so long as treatment was continued, but the disease appeared after the treatment was stopped. Similar treatments of leukemic AKR mice deferred the fatal issue significantly. However, the leukemic process was suppressed and not cured. Germfree AKR mice offer distinct experimental advantages for studies on leukemia.
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