Differential Immunogenicity of H -2 Alloantigens: A Sensitive Immuno-Pharmacologic Test 1

Abstract

Summary

Allograft reactions directed against antigens of the entire H-2^b allele or of its K and D ends were compared in 3 congenic-resistant strains of mice sharing the C57BL/10 background. Lymphoma cells of B10 origin were transplanted into partially immunodepressed mice; residual host antigraft immunity was potentiated by a single administration of the antitumor agent BCNU. The immunogenicity of H-2^b components was distinct and additive, with strength of elicited allograft reactions decreasing in the following order: D + K>K>D.