Abstract
Summary
In tissue culture leucogenenol increases the RQ and decreases the oxygen consumption of lymphoblastoid cells that originate from normal humans, while it decreases the RQ and increases the oxygen consumption of lymphoblastoid cells that originate from humans suffering neoplastic blood diseases. Strains of lymphoblastoid cells that originate from normal humans are indistinguishable so far as the effect of leucogenenol on them is concerned. Lymphoblastoid cells that originate from neoplastic tissues, however, show a RQ and rate of oxygen consumption and the effect of leucogenenol on the RQ and rate of oxygen consumption that is characteristic of the neoplastic origin of the lymphoblastoid cells. It is suggested that leucogenenol affects those enzyme systems that are associated with the transformation of cells and perhaps malfunction of the same systems is associated with neoplastic diseases.
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