Inhibition of Adenovirus Type 2 by Human and Monkey Interferon

Abstract

Summary

Human adenovirus type 2 was inhibited to a greater extent by monkey interferon than by human interferon in the cell culture systems used. In both assay systems, i.e., infectivity assays and immunofluorescent staining procedures, a single dose of monkey interferon reduced Ad 2 growth in Vero cell cultures 96-98%, while a 65-80 inhibition was observed with human interferon. The effect of interferon on the total population of infected cells was twofold. The number of cells showing positive fluorescence was reduced in addition to a reduction in the amount of capsid antigens in those cells demonstrating positive fluorescence. These studies suggest that at least certain serotypes of human adenoviruses are sensitive to interferon from animals other than their natural host.