Peripheral Metabolism of Thyroxine in Thyroidectomized Rats Treated with Cortisone 1

Abstract

Summary

The present study supports the conclusion that cortisone, administered to thyroidectomized, thyroxine-maintained rats does not alter their ability to deiodinate peripheral thyroxine. This is based on the observation that in two separate experiments there was no demonstrable cortisone effect on the level of serum protein-bound protein iodine. In addition, there was no significant difference between control and cortisone-treated animals in regard to either their urinary or fecal ¹²³I excretion as well as no difference in total excretion of radioactivity.