Abstract
Summary
Guinea pigs on an oxidatively rancid, ascorbic acid-free test diet showed a lesser degree of scurvy when compared to overtly scorbutic animals on the nonrancid ascorbic acid-free test diet. Simultaneous administration of alpha tocopherol, an antioxidant and free radical scavenger, to guinea pigs on the rancid, ascorbic acid-free diet blocked the antiscorbutic effect. It is postulated that lipid peroxidation may act antiscorbutically by supplying the free hydroxyl radical ordinarily arising in the presence of ascorbic acid.
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