Abstract
Summary
Poly I:C administered iv 3 hr prior to challenge with IBR virus did not prevent infection but did alter the severity of respiratory disease. Poly I:C-treated calves had much milder clinical manifestations of respiratory illness than the untreated controls. Depending on the dosage used, Poly I:C reduced or prevented the pneumonic lesions in the lungs. Complete protection from these lesions was provided by a dose of 1 mg/kg of body wt. Poly I:C induced only modest levels of putative circulating interferon in calves.
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