Abstract
Summary
Repeated resection and reimplantation of the pituitary tumor MtT/W5 in W/Fu rats leads to the appearance of metastatic tumor chiefly in the ovaries and long bones. Metastatic tumor begins to appear about 15 weeks after initial subcutaneous implantation. Subtransplantation of some of the metastatic tumors results in a number of stable somatotropic tumors devoid of mammotropic activity. Whether this change in secretory activity is due to cloning or transformation cannot be determined at this time.
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