Abstract
Summary
Salmon calcitonin, a potent diuretic, natriuretic, phosphaturic agent in the intact rat, was found to be inactive in this regard in the adrenalectomized rat while maintaining full hypocalcemic activity. Pre-treatment of adrenalectomized rats with hydrocortisone alcohol partially restored the natriuretic effect of salmon calcitonin, but did not duplicate effects observed in the intact rat. Other adrenal hormones were independently ineffective in restoring the urine electrolyte effects of salmon CT in the adrenx rat under the experimental conditions utilized.
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