Abstract
Summary
The effect of octanoate and palmitate on growth hormone synthesis by isolated rat pituitaries was studied. Octanoate had an impressive inhibitory effect on the incorporation of leucine-14C into pituitary growth hormone. The more physiological fatty acid palmitate however, had no effect on incorporation of leucine-14C into pituitary growth hormone. This latter finding suggests that the in vivo inhibitory effect of lipids on growth hormone secretion can not be explained by a direct inhibitory effect on pituitary growth hormone synthesis.
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