Abstract
Summary
N,N-Dimethyl-p-(m-tolylazo) aniline (3'-Me-DAB), mixed either in powdered Purina Laboratory Chow or in semisynthetic diet was fed to rats for 4 months. The animals were then returned to their respective basic diet for the next 2 months, when the experiment was terminated and the animals examined for possible lesions. Male Osborne-Mendel rats on chow diet showed a hepatoma incidence of 40, 67, and 100% in rats receiving 0.06, 0.09, and 0.098% 3'-Me-DAB, respectively, and female rats showed a hepatoma incidence of 0, 33, and 100% in animals receiving 0.06, 0.09, and 0.12% 3'-Me-DAB, respectively. The carcinogen concentration of 0.12 and 0.18% was too toxic for male and female rats, respectively. In the rats receiving 0.06% 3'-Me-DAB in semisynthetic diet, hepatoma incidence was 100% in all groups except NIH black where it was 90%.
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