Abstract
Summary
An attempt was made in this study to ascertain with what degree of validity and reproducibility the maximum PAH concentration during stop flow represents the best proximal sample. It has been shown that the diuretic chosen for stop flow studies will determine the location of the PAH peak by its effect on distal water reabsorption. With distal water reabsorption effectively inhibited with hypertonic mannitol infusion as indicated by decreased distal U/P cr, the stop flow patterns for PAH concentration in the proximal tubule is shown to approach a normal distribution. With increased distal water reabsorption, the stop flow patterns for proximal PAH concentration are shown to be skewed to the left, indicating a distal shift of the PAH peak from its proximal secretory site.
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