Abstract
Summary
Deficient DNA repair in fibroblasts from xeroderma pigmentosum is expressed as markedly reduced survival after low doses of uv. However, the life-span in vitro of XP cells is not reduced below normal age-matched controls. Senescence of normal cells in vitro, measured by decreased plating efficiency, appears before any measurable decline in either the capacity for DNA repair or survival following uv. In no cases was spontaneous transformation to permanent cell lines observed. It is concluded that failure in DNA repair is probably not causal to aging in vitro or in vivo.
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