Abstract
Summary
The ip administration of 1.5 g/kg of D-galactosamine HCl in a single injection resulted in profound histological and biochemical evidence of hepatocellular injury.
Electron microscopy disclosed focal cytoplasmic degeneration 6 hr after injection and this was paralleled by a progressive increase in the serum levels of glutamic oxaloacetic transaminase and glutamic pyruvic transaminase. Progressive cellular injury was accompanied by lipid accumulation, hyperplasia of the smooth endoplasmic reticulum, and organelle injury involving almost every cell. Although liver triglyceride levels were normal 6 hr following D-galactosamine administration, at 24 hr significant hepatic triglyceride accumulation was demonstrated. Serum enzyme levels, histologic features of the liver, and hepatic triglyceride content remained normal in animals treated with equimolar D-glucosamine HCl and 2-deoxy galactose.
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