Abstract
Summary and Conclusion
From these observations, we conclude:
1. Fragments of kidney, implanted in subcutaneous tissue undergo coagulation necrosis similar to necrosis which supervenes after ligation of the renal artery. The necrosis may result from failure of the kidney to elicit a prompt vascular response in the surrounding tissue within the implant. Scattered fragments of pelvic transitional epithelium remain viable.
2. Osteogenesis is observed in more than one-third of the implants as early as 14 days after implantation; yet the size of bone tissue is small at this time and a single section through the tissue may not disclose it.
3. implantation of cortex alone results in no bone formation. The likely stimulus to bone formation is the transitional pelvic epithelium which is implanted along with the medulla.
4. Implantation of kidney fragments in subcutaneous tissue seems to unify two previous models frequently used to study heterotopic osteogenesis; i.e., ligation of renal artery and transplanation of bladder epithelium.
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