Abstract
Summary
Actomyosin concentration, its viscosity response to ATP, and total phosphorus levels in subcellular fractions were determined in fasted (1-5d) and alloxan diabetic (3-210d) rats. No alterations in these parameters were detected as a result of fasting. However, during alloxan diabetes cardiac actomyosin ATPase activity was reduced for at least 7 days following alloxan administration and returned to normal levels 14 days after alloxan injection. These transitory toxic effects on cardiac muscle indicate that alloxan is not specifically beta cytotoxic.
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