Comparative Studies of SV 40 and Adenovirus Oncogenesis in Random Bred and Inbred Hamsters 1

Abstract

Summary

Inbred LSH and MHA hamsters were compared with random bred LVG hamsters for susceptibility to induction of tumor by SV₄₀, adenovirus 7, or adenovirus 12 viruses and for appearance of tumor after homologous transplantation. The LSH inbred strain proved superior to the MHA inbred line in trems of susceptibility to induction of tumor by SV₄₀ and adenovirus 7 virus and showed a shorter latent period after transplant with homologous SV₄₀ virus tumor. The LSH animals were also somewhat better than MHA hamsters from the point of view of husbandry. The susceptibilities of the inbred LSH and random bred LVG animals to induction of tumor by viruses were similar and the transplantation characteristics of tumors evolved in the two breeds of animals were approximately the same. The inbred LSH hamster provides a satisfactory model for induction of tumor by virus and for investigations of transplant tumor immunology employing a truly syngeneic system.