Abstract
Summary
The relationship in mice between immune status to polyinosinic·polycytidylic acid (poly I·Poly C) and interferon induction by poly I·Poly C was studied in vivo and in vitro. Circulating antibody to poly I·Poly C reduced the in vivo interferon response to poly I·Poly C. A similar but less profound inhibitory effect of specific antibody upon interferon induction was demonstrated in vitro. The findings imply that antibody-poly I·Poly C immune complexes are less potent interferon inducers than poly I·Poly C without antibody. Immunological tolerance to poly I·Poly C did not alter interferon induction by poly I·Poly C indicating dissociation between immunological status and interferon induction with this synthetic RNA in vivo.
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