Abstract
Summary
Pyran copolymer markedly sensitizes mice to the lethal effects of endotoxin. The sensitization occurs throughout both phases of RES activity. Pyran action on microsomal enzymes necessary for the metabolism of hexobarbital or antipyrine is not responsible for the sensitization because reversal of this activity with chlorcyclizine does not alter endotoxin sensitization. Preheparinization of pyran-treated mice only slightly prolonged the survival time, but did prevent the kidney damage.
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