Abstract
Summary
Intravenous injection of tolbutamide (15.0 mg/kg) caused a significant decrease of plasma FFA and BS concentration in geese and ducks, but not in owls. The decrease of plasma FFA was significant 5 min after the injection whereas the decrease of BS became significant first at 15 min of injection. The decrease of plasma FFA produced by tolbutamide in geese and ducks whose plasma FFA had been elevated by continuous infusion of glucagon (0.2 μg/kg/min) was not greater than that observed in intact birds injected with the same dose of the drug. Glucagon infusion in geese previously injected with tolbutamide caused an elevation of plasma FFA comparable to that observed when glucagon was infused at the same rate in intact birds. These results indicate that tolbutamide does not inhibit the adipokinetic effect of glucagon in vivo.
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