Abstract
Summary
The effects of an estrogen (mestranol), a progestational agent (norethindrone), and a combination of the two hormones on plasma zinc concentration, growth, and zinc-65 uptake in selected tissues were investigated in female rats fed a zinc-sufficient diet. Mestranol significantly (p<0.02) lowered plasma zinc concentration whereas norethindrone had no effect. Mestranol caused a significant increase in the uptake of a single injected dose of zinc-65 in the liver, spleen, adrenals, and uterus. Mestranol also caused a significant decrease in the growth.
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