Abstract
Summary
U-29,409 [2,3-dihydro-2-(1-naphthyl)-4(1H)-quinazolinone] is an antifertility compound in the rat. Antifertility is due to inhibition of spermatogenesis—which is accomplished by sc, ip, or oral treatment administered as single or multiple doses. Lowered fertility commences in the second week and may continue, depending upon severity of the dose, through the tenth week. Libido, as measured by ability and desire to mate, is not altered. U-29,409 affects spermatogenesis with a massive exfoliation of immature germinal cells which then migrate from the testis to the excurrent ducts.
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