Abstract
Summary
Samples of renal venous plasma were obtained from dogs in which a lung from another dog was interposed in the renal artery. The lung was ventilated with various gas mixtures. In this way it was possible to locally alter the oxygen tension and flow rate of the perfusing blood. Reduction of oxygen tension to 6 mm Hg for 17 min was without effect on renin activity. Reduction of blood flow raised renin activity and superimposition of near anoxia failed to alter this changed activity. Therefore, these studies do not provide evidence for an acute local effect of hypoxia on renin secretion.
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