Abstract
Summary
Prolonged treatment with poly I·Poly C was effective in suppressing the development of virus-induced murine sarcoma and the resultant mortality in infected mice. However, treatment at the dosage used was ineffective in preventing the infection of these mice by the murine leukemia virus present in excess in stocks of murine sarcoma virus. The poly I·Poly C treated virus-infected mice eventually developed lymphoma, and their spleens contained both murine leukemia, group-specific, complement-fixing viral antigens and infectious murine leukemia virus. These experiments suggest that poly I·Poly C treatment may not be effective against Friend and Rauscher leukemia viruses at high challenge doses.
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