Abstract
Summary
The polycation diethylamino-ethyl-dextran (DEAE-D) enhanced the oncogenicity of Moloney sarcoma virus (M-MSV) in mice as measured by several parameters including shortening of the latent time to tumor appearance, reduction of the minimal tumor inducing dose, decreased survival time, and decreased incidence of spontaneous regressions. Enhancement occurred following both local and systemic administration of DEAE-D, and was greater when DEAE-D was administered prior to virus inoculation. The degree of in vivo enhancement of M-MSV by DEAE-D was similar to the enhancement of focus formation in tissue culture.
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