Abstract
Summary
Pancreatic islet cell tumors (nesidioblastomas) were produced in 64% (18/28) of the male Holtzman rats treated with both streptozotocin and nicotinamide, while only one tumor was noted in 26 male Holtzman rats treated with streptozotocin alone, and none in rats treated with nicotinamide alone or with the streptozotocin vehicle. The majority of these neoplasms occurred in animals sacrificed 14-18 months after treatment. Hypoglycemia, intensely basophilic cytoplasmic granulation in the islet tumors, and the presence of immunoreactive insulin in tumor extracts indicate that the adenomas secreted insulin.
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