Abstract
Summary
Injection of live E. coli organisms to dogs iv causes a lethal shock. Administrations of anti-inflammatory drugs (indomethacin, aminopyrine, flufenamic acid, and phenylbutazone) block partially the effect of shock on the mean systemic arterial blood pressure, on the portal vein pressure, and on the hematocrit values. The changes that follow the injection of E. coli were significantly different in the treated animals from those in the control group. Some of the other agents tested were ineffective. Thus only drugs which have an antiphlogistic effect protected against shock.
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