The Effect of Estradiol-17β and Vegetable Oil on the Hydroxylation of Protocollagen 1

Abstract

Summary

Estradiol-17β dissolved in sesame oil increased the activity of proline hydroxylase as measured by the release of tritium from protocollagen containing triti-ated proline. Sesame seed oil alone was responsible for the major part of this effect. The increases produced by the addition of estradiol to sesame seed oil were marginally significant. Studies with constituents of sesame seed oil showed that unsaturated fatty acids, such as oleic, palmitoleic, and linoleic acids, were active. Myristic acid was inactive.