Abstract
Summary
Immunization of chickens with live avian sarcoma virus RSV(RAV-1) or with its helper leukosis virus, RAV-1, afforded high levels of protection against sarcoma induction by RSV(RAY-1). The sarcoma virus was used in subtumorigenic doses and the RAV-1, which is of low overt oncogenicity, was used in a concentration of 106 tissue culture infectious units. Tn most cases, birds resisting tumor formation possessed high levels of virus neutralizing antibody. The role of antibody and cell-mediated immunity in avian sarcoma in which the etiologic agent persists in infectious form is discussed.
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