Abstract
Summary
a. MIT used in the present work was found to be a useful method for the evaluation of sensitization occurring in oncological experimental systems, where transplantation tests may fail due to high virulence of the tumor.
b. Both cell lines used, L-1 and L-2c, which are established tumorogenic cell lines derived from the C3H strain, sensitize isogenic hosts when injected sc.
c. No cross-reaction between the two cell lines could be demonstrated by the MIT as used in this work.
d. Both cell lines sensitize hosts of DBA strain across H-2. However, only slight signs of cross-reaction were seen, when DBA spleen sensitized this way was challenged by C3H spleen cell homogenate.
e. Experiments on tumors derived from the tumorogenic cell lines show cross-reactions with the original cell lines.
f. Slight signs of autoimmunization were observed in C3H mice after sensitization by the transformed cell lines, when challenged by the normal C3H spleen homogenate.
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