Abstract
Summary
Renal cortical slices from 1-week-old rabbits, dogs, and cats accumulated PAH to a lesser extent than slices from adult animals, while the values in 1-week-old guinea pigs were higher than those obtained in adults. Although penicillin treatment resulted in a significant increase in PAH accumulation, no histological differences between kidneys from treated and control rabbits could be observed using light microscopy. Normal histological maturation of new-born rabbit kidneys could be detected. It is concluded that the substrate-induced stimulation of PAH accumulation produced by penicillin involves specific subcellular changes (structural and/or biochemical) in the organic acid transport mechanism.
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