Abstract
Summary
Mongrel dogs were anesthetized and bled until mean arterial blood pressure was reduced to about 40 mm Hg. After the blood pressure had stabilized at this level, doxapram HCl (20 mg/kg) or an equivalent volume of saline was given intravenously. Experiments were always conducted in pairs, with one dog for each treatment. In animals given doxapram HCl, there was a prompt increase in arterial blood pressure and respiratory function while essentially no favorable change was seen following injection of saline in control animals. Also, doxapram HCl-treated dogs recovered quickly and this group showed a 90% survival rate as compared to 30% in the controls. These results are interpreted as indicative of beneficial effects of doxapram HCl in experimental hemorrhagic hypotension.
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