Abstract
Summary
Uterotropic and antifertility properties of the resoreylic acid lactone derivative, zearalane, and its 7′-formyl and 7′-carboxy analogues have been evaluated. Additions at the 7′-position enhanced the estrogenic and anti-implantation activities of zearalane. The more active isomer of 7′-car-boxy zearalane proved to be at least 100 times as estrogenic as zearalane and one-tenth as active as DES. Anti-implantation potency was increased in a corresponding manner.
There was no unequivocal separation of estrogenic and anti-implantation activities noted in any of the compounds tested.
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