Abstract
Summary
Chlorpromazine-induced hyperglycemia is abolished by adrenalectomy in mice. The administration of beta-adrenergic blocking agents failed to alter the magnitude of the CPZ-induced hyperglycemia. Similarly, beta-adrenergic blockade does not influence epinephrine-induced hyperglycemia in mice. Since beta-adrenolytic agents block both CPZ- and epinephrine-induced hyperglycemia in rats, the results of the present studies suggest a species difference in the susceptibility of certain adrenergic receptors to beta blockade.
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