Abstract
Summary
The metabolism of nuclear and cytoplasmic ribonucleic acid (RNA) of a 90Sr-induced rat chloroleukemia was characterized and the effects of chemotherapeutic agents on this RNA metabolism studied.
The in vitro 3H-uridine incorporation into nuclear and cytoplasmic RNA of this tumor is inhibited by certain chemotherapeutic agents. The following chemotherapeutic agents were studied: vinblastine sulfate; polyinosinic-polycytidylic acid; L-asparaginase; cytosine arabinoside; Daunomycin; hydrocortisone; 6-methylmercaptopurine ribonucleoside; DL-threonine (utilized as a serine antagonist). In general, the chemotherapeutic agents tested appeared to interfere with 3H-uridine incorporation into cytoplasmic and nuclear RNA. Preliminary evidence suggests poor correlation between in vivo destruction of tumor and in vitro 3H-uridine incorporation into nuclear or cytoplasmic RNA with vinblastine sulfate, L-asparaginase, and polyinosinic-polycytidylic acid.
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