Abstract
Summary
Aqueous extracts of rat aorta (NAE) induces increased tension in helically-cut arterial strips in vitro. Muscle shortening is not seriously impaired in strips treated with an alpha-adrenergic blocking drug. This effect is not obtained with similar extracts of stomach, myocardial, or skeletal muscle. Also, no significant strip tension is observed with extracts of aortas from rats treated with protein synthesis inhibitors, actinomycin D, puromycin, or acetoxycycloheximide. Vasoactivity of NAE persists after heating to 100° but is destroyed by trypsin digestion.
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