Abstract
Summary
The amniotic fluid from 38 control and 5 heterozygote TSD mothers were analyzed by acrylamide gel electrophoresis and heat fractionation for the percent of hexosaminidase A activity. This study indicates that amniotic fluid, when analyzed by acrylamide gel electrophoresis, can be used for the prenatal diagnosis of TSD.
ADDENDUM
Since this paper was submitted for publication, the amniotic fluids of 35 additional normal (non-Tay-Sachs) pregnant women, 3 pregnant Tay-Sachs mothers (predicted normal) and 2 pregnant Tay-Sachs mothers (predicted Tay-Sachs) were analyzed for total hexosaminidase and hexosaminidase A content with both the heat fractionation and acrylamide gel procedures. The results obtained extend and confirm the findings reported in this paper.
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