Effects of the Metabolites of Prostaglandin E 1 of the Systemic and Peripheral Circulations in Dogs 1

Abstract

Summary

The effects of PGE₁ and its three metabolites, 15-keto-PGE₁, dihydro-PGE₁, and 15-keto-dihydro-PGE₁, were studied in anesthetized dogs and in isolated dog hind limb preparations. The systemic hemodynamic effects of these three metabolites were qualitatively similar to those of PGE₁ in dogs, but the magnitude of the effects was smaller with these three metabolites than with PGE₁. Among these metabolites, dihydro-PGE₁ exerted the most potent hemodynamic and vasodilator actions. The present study suggests that the inactivation of PGE₁ in the lungs is caused, not by the saturation of the Δ¹³ durable bond of PGE₁, but by the oxidation of the secondary alcohol group at C-15 and probably by further degradation.