Abstract
Summary
During the second day after an im injection of 1 mg of cadmium/kg of body weight, normal 200 g rats averaged 42 μEq less urinary sodium than control animals. This antinatriuretic effect increased with successive doses of cadmium, reaching an average of 68 μEq after the fourth such dose. There was a corresponding increase in weight on the day after each cadmium injection. Rebound natriuresis was observed 1 and 2 weeks after the first dose of cadmium; it was less evident after the second dose and was completely absent after the third and fourth doses. Cadmium produced no corresponding change in urinary volume, protein, potassium, cadmium, or zinc. Six months after the fourth cadmium injection, there was no hypertension but there was a suggestive, if insignificant, increase in peripheral renin as well as a decrease in responsiveness to nor-epinephrine but not to either angiotensin or cadmium.
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