Abstract
Summary
4-Hydroxyaminoquinoline-1-oxide and its O,O'-diacetyl derivative were compared with respect to their abilities to induce skin tumors in mice (with subsequent application of croton oil) and to induce sarcomas at the site of sc injection in rats or mice. The two compounds had approximately equal activities in the two mouse assays; however, the diacetyl derivative was much less active than its parent compound in the induction of sarcomas in rats.
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