Abstract
Summary
Antigens synthesized in HeLa cells infected with adenovirus type 12 were studied by direct and indirect immunofluorescence. Sera used to detect these antigens were antiviral guinea pig sera and sera from hamsters bearing adenovirus type 12 tumors. Most of the hamster sera reacted with T antigens; however, less than 50% of these sera reacted with an exclusively intranuclear antigen and an antigen found at the cell membrane. The latter two antigens were not synthesized in the presence of FUDR or when infected cells were maintained at 25° thereby requiring the synthesis of DNA.
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