Abstract
Summary
The in vitro response to phytohemagglutinin (PHA) and pokeweed mitogen (PWM) of lymphoid cells from thymectomized, irradiated, bone marrow reconstituted (TIR) mice was compared to that of intact age controls. TIR spleens, lacking cells of the thymus-dependent compartment, responded only to pokeweed mitogen, whereas spleens from intact donors responded to both PHA and PWM. These results suggest that PHA stimulates thymus-dependent cells; whereas PWM stimulates cells of the non-thymus-dependent compartment.
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