Abstract
Summary
Marked and sustained elevation of systolic and diastolic blood pressure results from the continuous iv infusion of angiotensin II in anesthetized dogs.
The administration of hydralazine, sodium nitrite, and hexamethonium (10 mg/kg, iv) produced a fall in blood pressure in angiotensin-induced hypertensive dogs. However, hydralazine failed to produce a hypotensive response in normotensive dogs. This suggests the possibility that antihypertensive drugs may be evaluated in dogs made acutely hypertensive by angiotensin II infusion.
Get full access to this article
View all access options for this article.