Abstract
Summary
Human and rabbit globulins possessing Escherichia coli agglutinating activity reacted with antigens present in normal and diseased (ulcerative colitis) rectal mucosa. The direct immunofluorescent staining technique gave positive results when OB E. coli strains were tested. Staining was most marked in the basement membrane of the nucosal glands, and in the basal portion of the acinar epithelial cells. Sections of ulcerative colitis rectal tissue showed increased staining of interstitial leukocytes. The observed effects were independent of the donor blood types and did not follow the distribution of blood group substance in rectal mucosa.
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