Abstract
Summary
The effects of a single injection of gold thioglucose (GTG) and bipiperidyl mustard (BM) on the pituitary prolaction and GH contents of C3H mice were studied. Virtually all mice receiving the drugs became obese in 8 weeks. GTG and BM increased pituitary prolactin concentration 37 and 24% at 4 weeks and 42 and 40%, respectively, at 8 weeks (p<0.01). GH concentration was enhanced significantly (30%; p<0.01) only by BM treatment at 8 weeks, BM increased the weights of the pituitary glands, adrenals, ovaries, and the uteri; whereas only the uterine weights were increased by GTG treatment. The data suggest that prolactin and/or GH may be related to the induction of obesity by GTG and BM.
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