The Effect on Myocardial 3 H-Digoxin of Magnesium Deficiency 1

Abstract

Summary

The hearts of magnesium-deficient mice accumulate less ³H-digoxin 1 hr after intraperitoneal injection than do controls. At 3, 6, 18, and 24 hr, magnesium-deficient mice retained more ³H-digoxin than controls. The difference in the initial uptake of ³H-digoxin between control and magnesium-deficient animals is not due to different blood ³H-digoxin levels. The role of magnesium deficiency-induced potassium deficiency in altering myocardial ³H-digoxin metabolism is discussed.