Abstract
Summary
The in vitro effect of dieldrin (HEOD) on respiration of rat liver mitochondria was studied. It was found that HEOD inhibited mitochondrial respiration at a site prior to the DNP-sensitive coupling site. Further work showed that HEOD inhibited electron transport in the mitochondrial electron chain in the cytochrome B area; terminal chain electron transport was not effected by HEOD. The effect of HEOD was dependent upon the level of mitochondrial protein and not on the molar concentration of the pesticide in the reaction mixture.
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