Abstract
Summary
The antilipolytic activity of the beta-adrenergic blocking drug, 4-(2-hydroxy-3-isopropylaminopropoxy) acetanilide (practolol), was examined using the isolated fat cell preparation. The compound was found to be a competitive inhibitor of hormone-stimulated lipolysis with low intrinsic activity. As determined by pA2 values the compound was 80-100 times less potent than propranolol. In contrast to propranolol, practolol did not inhibit the lipolytic response to dibutyryl cyclic AMP nor ACTH. Practolol also failed to inhibit glucose oxidation.
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